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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
1998 1
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2002 1
2003 1
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2005 2
2009 2
2010 1
2011 1
2013 3
2014 3
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2017 2
2019 2
2021 3
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27 results

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Page 1
Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients.
Sha R, Zhang J, Meng F, Zhaori G. Sha R, et al. Medicine (Baltimore). 2023 Oct 6;102(40):e35030. doi: 10.1097/MD.0000000000035030. Medicine (Baltimore). 2023. PMID: 37800836 Free PMC article.
METHODS: All GC data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. The metastasis-related candidate gene and its role in GC were analyzed by comprehensive analysis. RESULTS: Totally 1049 metastasis-related genes were identi …
METHODS: All GC data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. The metastasis-related candida …
cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer.
Cole KA, Chuaqui RF, Katz K, Pack S, Zhuang Z, Cole CE, Lyne JC, Linehan WM, Liotta LA, Emmert-Buck MR. Cole KA, et al. Genomics. 1998 Jul 15;51(2):282-7. doi: 10.1006/geno.1998.5359. Genomics. 1998. PMID: 9722952
We recently identified a novel gene (PB39) (HGMW-approved symbol POV1) whose expression is up-regulated in human prostate cancer using tissue microdissection-based differential display analysis. In the present study we report the full-length sequencing of …
We recently identified a novel gene (PB39) (HGMW-approved symbol POV1) whose expression is up-regulated in human prosta …
Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor.
Rii J, Sakamoto S, Sugiura M, Kanesaka M, Fujimoto A, Yamada Y, Maimaiti M, Ando K, Wakai K, Xu M, Imamura Y, Shindo N, Hirota T, Kaneda A, Kanai Y, Ikehara Y, Anzai N, Ichikawa T. Rii J, et al. Cancer Sci. 2021 Sep;112(9):3871-3883. doi: 10.1111/cas.14991. Epub 2021 Jul 8. Cancer Sci. 2021. PMID: 34050700 Free PMC article.
L-type amino acid transporter 3 (LAT3, SLC43A1) is abundantly expressed in prostate cancer (PC) and is thought to play an essential role in PC progression through the cellular uptake of essential amino acids. ...In chromatin immunoprecipitation sequencing of AR, bin …
L-type amino acid transporter 3 (LAT3, SLC43A1) is abundantly expressed in prostate cancer (PC) and is thought to play an esse …
Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells.
Xu SM, Tang K, Meng L, Tang Y. Xu SM, et al. J Huazhong Univ Sci Technolog Med Sci. 2013 Oct;33(5):632-635. doi: 10.1007/s11596-013-1171-2. Epub 2013 Oct 20. J Huazhong Univ Sci Technolog Med Sci. 2013. PMID: 24142711
We also evaluated cell viability using a methyl thiazolyl tetrazolium (MTT) assay after blocking LAT3 expression with either shRNA targeted to LAT3 or a small molecular inhibitor BCH (2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid). LAT3 mRNA and protein ex …
We also evaluated cell viability using a methyl thiazolyl tetrazolium (MTT) assay after blocking LAT3 expression with either shRNA ta …
EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer.
Zhang BK, Moran AM, Bailey CG, Rasko JEJ, Holst J, Wang Q. Zhang BK, et al. Cell Commun Signal. 2019 Jul 25;17(1):83. doi: 10.1186/s12964-019-0400-0. Cell Commun Signal. 2019. PMID: 31345230 Free PMC article.
In primary prostate cancer cells, intracellular leucine levels are regulated by L-type amino acid transporter 3 (LAT3/SLC43A1), and we therefore investigated whether LAT3 is regulated by growth factor signalling. ...These effects were likely due to stabilisat …
In primary prostate cancer cells, intracellular leucine levels are regulated by L-type amino acid transporter 3 (LAT3/SLC43A1) …
Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth.
Wang Q, Grkovic T, Font J, Bonham S, Pouwer RH, Bailey CG, Moran AM, Ryan RM, Rasko JE, Jormakka M, Quinn RJ, Holst J. Wang Q, et al. ACS Chem Biol. 2014 Jun 20;9(6):1369-76. doi: 10.1021/cb500120x. Epub 2014 May 5. ACS Chem Biol. 2014. PMID: 24762008 Free PMC article.
Using Xenopus laevis oocytes expressing individual LAT family members, we demonstrated that ESK246 preferentially inhibits leucine transport via LAT3, while ESK242 inhibits both LAT1 and LAT3. We further show in LNCaP prostate cancer cells that ESK246 is a potent (I …
Using Xenopus laevis oocytes expressing individual LAT family members, we demonstrated that ESK246 preferentially inhibits leucine transport …
Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis.
Yue M, Jiang J, Gao P, Liu H, Qing G. Yue M, et al. Cell Rep. 2017 Dec 26;21(13):3819-3832. doi: 10.1016/j.celrep.2017.12.002. Cell Rep. 2017. PMID: 29281830 Free article.
MYC selectively activates Slc7a5 and Slc43a1 transcription through direct binding to specific E box elements within both genes, enabling effective EAA import. ...These findings thus reveal a MYC-SLC7A5/SLC43A1 signaling circuit that underlies EAA metabolism, …
MYC selectively activates Slc7a5 and Slc43a1 transcription through direct binding to specific E box elements within both genes …
Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer.
Chu CE, Alshalalfa M, Sjöström M, Zhao SG, Liu Y, Chou J, Herlemann A, Mahal B, Kishan AU, Spratt DE, Cooperberg M, Small E, Wong A, Porten S, Hope TA, Ross AE, Davicioni E, Nguyen P, Karnes RJ, Carroll PR, Schaeffer E, Feng FY. Chu CE, et al. Eur Urol. 2021 Jun;79(6):717-721. doi: 10.1016/j.eururo.2021.03.017. Epub 2021 Apr 8. Eur Urol. 2021. PMID: 33840559
The top decile of PSMA expression was associated with poorest metastasis-free survival (MFS), while the bottom deciles of LAT3 and ASCT2 expression were associated with poorest MFS. PATIENT SUMMARY: We measured the expression of genes that encode the targets for two …
The top decile of PSMA expression was associated with poorest metastasis-free survival (MFS), while the bottom deciles of LAT3 and AS …
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.
Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman ML, Hendy SC, Buchanan G, Nelson CC, Rasko JE, Holst J. Wang Q, et al. Cancer Res. 2011 Dec 15;71(24):7525-36. doi: 10.1158/0008-5472.CAN-11-1821. Epub 2011 Oct 17. Cancer Res. 2011. PMID: 22007000
L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cancer cells coordinate the expression of LAT1 and LAT3 to maintain sufficient levels of leucine needed for mTORC1 signaling and cell grow …
L-Type amino acid transporters such as LAT1 and LAT3 mediate the uptake of essential amino acids. Here, we report that prostate cance …
PRADclass: Hybrid Gleason Grade-Informed Computational Strategy Identifies Consensus Biomarker Features Predictive of Aggressive Prostate Adenocarcinoma.
Balraj AS, Muthamilselvan S, Raja R, Palaniappan A. Balraj AS, et al. Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338231222389. doi: 10.1177/15330338231222389. Technol Cancer Res Treat. 2024. PMID: 38226611 Free PMC article.
RESULTS: The statistical modeling yielded 77 Gleason grade-salient genes while the WGCNA algorithm yielded 1003 trait-specific key genes in grade-wise significant modules. Consensus analysis of the two approaches identified two genes in Grade-1 (SLC43A1 …
RESULTS: The statistical modeling yielded 77 Gleason grade-salient genes while the WGCNA algorithm yielded 1003 trait-specific key …
27 results